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KMID : 0381019930260050524
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Korean Journal of Nutrition
1993 Volume.26 No. 5 p.524 ~ p.531
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The Changes of Erythrocyte Feature and Ca Concentration in Rat Fed the Diet Containing Different Common Oils in Korea : Sesame Oil, Perilla Oil, Rice Oil, Rice Bran Oil and Mixed Oil
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Abstract
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This study was done to investigate the effects of different dietary oils on hepatic mitochondrial lipid composition, adenine nucleotide translocase(AdNT) and ATP ase activities in carcinogen treated rats. Sixty male Sprague-Dawley rats, weighing
50~60g,
were fed three different types of dietary oil, beef tallow(BT), corn oil (CO) and sardine oil(SO) at 15%by weight for 14 weeks. Three weeks after feeding, rats were intraperitoneally injected with a single dose of diethylnitrosamine(200mg/Kg BW).
After
five weeks rats were fed 0.02% acetylaminofluorene containing diet for 6 weeks, and after seven weeks 0.05% phenobarbital containing diet for 7 weeks. At 14th week, rats were sacrificed and hepatic mitochondrial lipid composition, AdNT and ATPase
activities were determined.
Percent liver weight per body weight was significantly increased by carcinogen treatment. Analysis of mitochondrial lipid composition showed that both cholesterol and phospholipid contents were not affected by dietary oils but significantly
increased by
carcinogen treatment. Individual phospholipid composition as well as phosphatidyl ethanolamine/phosphatidyl choline ratio were altered by either dietary oils or carcinogen treatment. Fatty acid composition was changed by dietary oils but not much
by
carcinogen treatment. AdNT activity was affected by dietary oils in only carcinogen treated groups. ATP ase activity was affected by dietary oils in only carcinogen nontreated group.
These data indicate that both dietary oils and carcinogen can change mitochondrial lipid composition and thereby change AdNT and ATP se activities. Particularly effects of carcinogen treatment of cholesterol/phospholipid ratio, phospholipid
composition
and ATP ase activity were different among dietary oil groups. Therefore it is suggested that different dietary oils can somewhat modulate the changes of mitochondrial lipid composition and membrane bound enzyme activity during
hepatocarcinogenesis.
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